The effects of bioactive components from the rhizome of gastrodia elata blume (Tianma) on the characteristics of Parkinson's disease
Parkinson's disease (PD) is an age-related chronic neurodegenerative disease caused by the death and degeneration of dopaminergic neurons in the substantia nigra of the midbrain. The decrease of the neurotransmitter dopamine in the patient's brain leads to various motor symptoms. PD drugs...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Book |
| Published: |
Frontiers Media S.A.,
2022-11-01T00:00:00Z.
|
| Subjects: | |
| Online Access: | Connect to this object online. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
MARC
| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_3a2d21ae9c794d6ba3de119e21b0ac9d | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Changcheng Lu |e author |
| 700 | 1 | 0 | |a Shuhui Qu |e author |
| 700 | 1 | 0 | |a Zhangfeng Zhong |e author |
| 700 | 1 | 0 | |a Hua Luo |e author |
| 700 | 1 | 0 | |a Si San Lei |e author |
| 700 | 1 | 0 | |a Hai-Jing Zhong |e author |
| 700 | 1 | 0 | |a Huanxing Su |e author |
| 700 | 1 | 0 | |a Yitao Wang |e author |
| 700 | 1 | 0 | |a Cheong-Meng Chong |e author |
| 245 | 0 | 0 | |a The effects of bioactive components from the rhizome of gastrodia elata blume (Tianma) on the characteristics of Parkinson's disease |
| 260 | |b Frontiers Media S.A., |c 2022-11-01T00:00:00Z. | ||
| 500 | |a 1663-9812 | ||
| 500 | |a 10.3389/fphar.2022.963327 | ||
| 520 | |a Parkinson's disease (PD) is an age-related chronic neurodegenerative disease caused by the death and degeneration of dopaminergic neurons in the substantia nigra of the midbrain. The decrease of the neurotransmitter dopamine in the patient's brain leads to various motor symptoms. PD drugs mainly enhance dopamine levels but cannot prevent or slow down the loss of dopaminergic neurons. In addition, they exhibit significant side effects and addiction issues during long-term use. Therefore, it is particularly urgent to develop novel drugs that have fewer side effects, can improve PD symptoms, and prevent the death of dopaminergic neurons. The rhizome of Gastrodia elata Blume (Tianma) is a well-known medicinal herb and has long been used as a treatment of nervous system-related diseases in China. Several clinical studies showed that formula comprising Tianma could be used as an add-on therapy for PD patients. Pharmacological studies indicated that Tianma and its bioactive components can reduce the death of dopaminergic neurons, α-synuclein accumulation, and neuroinflammation in various PD models. In this review, we briefly summarize studies regarding the effects of Tianma and its bioactive components' effects on major PD features and explore the potential use of Tianma components for the treatment of PD. | ||
| 546 | |a EN | ||
| 690 | |a Parkisnon's disease | ||
| 690 | |a tianma (Gastrodia elata blume) | ||
| 690 | |a dopaminergic neurons | ||
| 690 | |a neuroinflmamation | ||
| 690 | |a synuclein | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Frontiers in Pharmacology, Vol 13 (2022) | |
| 787 | 0 | |n https://www.frontiersin.org/articles/10.3389/fphar.2022.963327/full | |
| 787 | 0 | |n https://doaj.org/toc/1663-9812 | |
| 856 | 4 | 1 | |u https://doaj.org/article/3a2d21ae9c794d6ba3de119e21b0ac9d |z Connect to this object online. |