Design, synthesis and evaluation of OA-tacrine hybrids as cholinesterase inhibitors with low neurotoxicity and hepatotoxicity against Alzheimer's disease

• Автори: Huali Yang (Автор), Hongwei Jia (Автор), Minghui Deng (Автор), Kaicheng Zhang (Автор), Yaoyang Liu (Автор), Yang Liu (Автор), Maosheng Cheng (Автор), Wei Xiao (Автор)
• Формат: Книга
• Опубліковано: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

A series of OA-tacrine hybrids with the alkylamine linker was designed, synthesized, and evaluated as effective cholinesterase inhibitors for the treatment of Alzheimer's disease (AD). Biological activity results demonstrated that some hybrids possessed significant inhibitory activities against...