Pharmacokinetics and pharmacodynamics of mibavademab (a leptin receptor agonist): Results from a first‐in‐human phase I study

• Main Authors: Andrew Gewitz (Author), Jeanne Mendell (Author), Yuhuan Wang (Author), Charles Harris (Author), Benjamin A. Olenchock (Author), Simona Podgrabinska (Author), Wenjun Zheng (Author), An Zhao (Author), Hao Pan (Author), Frédéric Vanhoutte (Author), John D. Davis (Author)
• Format: Book
• Published: Wiley, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Mibavademab (previously known as REGN4461), a fully human monoclonal antibody, is being investigated for the treatment of conditions associated with leptin deficiency. Here, we report pharmacokinetics (PKs), pharmacodynamics, and immunogenicity from a phase I study in healthy participants (...