A Bispecific, Tetravalent Antibody Targeting Inflammatory and Pruritogenic Pathways in Atopic Dermatitis

• Main Authors: Julia Tietz (Author), Tea Gunde (Author), Stefan Warmuth (Author), Christopher Weinert (Author), Matthias Brock (Author), Alexandre Simonin (Author), Christian Hess (Author), Maria Johansson (Author), Fabio Spiga (Author), Simone Muntwiler (Author), Belinda Wickihalder (Author), Dana Mahler (Author), Dania Diem (Author), Julia Zeberer (Author), Robin Heiz (Author), Naomi Flückiger (Author), Noriko Shiraishi (Author), Yoshihide Miyake (Author), Nobuaki Takahashi (Author), Markus Fehrholz (Author), Marta Bertolini (Author), Peter Lichtlen (Author), David Urech (Author), Daniel Snell (Author)
• Format: Book
• Published: Elsevier, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inhibition of IL-4/IL-13 signaling has dramatically improved the treatment of atopic dermatitis (AD). However, in many patients, clinical responses are slow to develop and remain modest. Indeed, some symptoms of AD are dependent on IL-31, which is only partially reduced by IL-4/IL-13 inhibition. Thu...