Consideration of Sex as a Biological Variable in the Development of Doxorubicin Myotoxicity and the Efficacy of Exercise as a Therapeutic Intervention

• Main Authors: Ryan N. Montalvo (Author), Vivian Doerr (Author), Branden L. Nguyen (Author), Rachel C. Kelley (Author), Ashley J. Smuder (Author)
• Format: Bog
• Udgivet: MDPI AG, 2021-02-01T00:00:00Z.
• Fag: article
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Doxorubicin (DOX) is an anthracycline antibiotic used to treat a wide variety of hematological and solid tumor cancers. While DOX is highly effective at reducing tumor burden, its clinical use is limited by the development of adverse effects to both cardiac and skeletal muscle. The detrimental effec...