LINE-1 methylation is inherited in familial testicular cancer kindreds

• Autores principales: Gadalla Shahinaz M (Autor), Korde Larissa (Autor), Savage Sharon A (Autor), Mirabello Lisa (Autor), Greene Mark H (Autor)
• Formato: Libro
• Publicado: BMC, 2010-05-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Testicular germ cell tumors (TGCT) are the most frequent cancers among young men. There is a clear familial component to TGCT etiology, but no high-penetrance susceptibility gene has been identified. Epigenetic aberrations of the gen...