Satisfaction survey with DNA cards method to collect genetic samples for pharmacogenetics studies

• Main Authors: Mas Herrero Sergio (Author), Cucala Mercedes (Author), Vidal-Taboada Jose M (Author), Lafuente Amalia (Author), Cobos Albert (Author)
• Format: Book
• Published: BMC, 2006-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

<p>Abstract</p> <p>Background</p> <p>Pharmacogenetic studies are essential in understanding the interindividual variability of drug responses. DNA sample collection for genotyping is a critical step in genetic studies. A method using dried blood samples from finger-puncture, collected on DNA-cards, has been described as an alternative to the usual venepuncture technique. The purpose of this study is to evaluate the implementation of the DNA cards method in a multicentre clinical trial, and to assess the degree of investigators' satisfaction and the acceptance of the patients perceived by the investigators.</p> <p>Methods</p> <p>Blood samples were collected on DNA-cards. The quality and quantity of DNA recovered were analyzed. Investigators were questioned regarding their general interest, previous experience, safety issues, preferences and perceived patient satisfaction.</p> <p>Results</p> <p>151 patients' blood samples were collected. Genotyping of <it>GST </it>polymorphisms was achieved in all samples (100%). 28 investigators completed the survey. Investigators perceived patient satisfaction as very good (60.7%) or good (39.3%), without reluctance to finger puncture. Investigators preferred this method, which was considered safer and better than the usual methods. All investigators would recommend using it in future genetic studies.</p> <p>Conclusion</p> <p>Within the clinical trial setting, the DNA-cards method was very well accepted by investigators and patients (in perception of investigators), and was preferred to conventional methods due to its ease of use and safety.</p>

Item Description

10.1186/1471-2350-7-45
1471-2350