Preemptive analgesia with ibuprofen increases anesthetic efficacy in children with severe molar hypomineralization: a triple-blind randomized clinical trial

• Main Authors: Fernanda Vicioni-Marques (Author), Francisco Wanderley Garcia de Paula-Silva (Author), Milena Rodrigues Carvalho (Author), Alexandra Mussolino de Queiroz (Author), Osvaldo de Freitas (Author), Maíra Peres Ferreira Duarte (Author), David John Manton (Author), Fabrício Kitazono de Carvalho (Author)
• Format: Book
• Published: University of São Paulo, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Abstract Molar incisor hypomineralization (MIH) is often accompanied by dental hypersensitivity and difficulty in achieving effective analgesia. Objective: This study evaluated the effectiveness of preemptive analgesia in children with severe MIH, post-eruptive enamel breakdown, and hypersensitivity. Methodology: Ibuprofen (10 mg/kg child weight) or placebo was administered, followed by infiltrative anesthesia and restoration with resin composite. Hypersensitivity was evaluated in five moments. The data were analyzed using the chi-square test, Fisher's exact test, and t-test. Results: Preemptive analgesia provided benefits for the treatment of severe cases of MIH, with an increase in the effectiveness of infiltrative anesthesia and improved patient comfort during the restorative procedure. Conclusion: Preemptive analgesia has shown efficacy in reducing hypersensitivity during restorative dental procedures, evidencing the significance of this study for patients with MIH and hypersensitivity.

Item Description

1678-7765
10.1590/1678-7757-2021-0538