Metformin acts as a dual glucose regulator in mouse brain

• Main Authors: Bo-Yeong Jin (Author), Hyun-Ju Kim (Author), Mi-Jeong Oh (Author), Na-Hee Ha (Author), Yong Taek Jeong (Author), Sang-Hyun Choi (Author), Jun-Seok Lee (Author), Nam Hoon Kim (Author), Dong-Hoon Kim (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aims: Metformin improves glucose regulation through various mechanisms in the periphery. Our previous study revealed that oral intake of metformin activates several brain regions, including the hypothalamus, and directly activates hypothalamic S6 kinase in mice. In this study, we aimed to identify t...