Targeted Anticancer Agent with Original Mode of Action Prepared by Supramolecular Assembly of Antibody Oligonucleotide Conjugates and Cationic Nanoparticles

• Main Authors: Victor Lehot (Author), Patrick Neuberg (Author), Manon Ripoll (Author), François Daubeuf (Author), Stéphane Erb (Author), Igor Dovgan (Author), Sylvain Ursuegui (Author), Sarah Cianférani (Author), Antoine Kichler (Author), Guilhem Chaubet (Author), Alain Wagner (Author)
• Format: Book
• Published: MDPI AG, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Despite their clinical success, Antibody-Drug Conjugates (ADCs) are still limited to the delivery of a handful of cytotoxic small-molecule payloads. Adaptation of this successful format to the delivery of alternative types of cytotoxic payloads is of high interest in the search for novel anticancer...