Engineered Aedes aegypti JAK/STAT Pathway-Mediated Immunity to Dengue Virus.

• Κύριοι συγγραφείς: Natapong Jupatanakul (Συγγραφέας), Shuzhen Sim (Συγγραφέας), Yesseinia I Angleró-Rodríguez (Συγγραφέας), Jayme Souza-Neto (Συγγραφέας), Suchismita Das (Συγγραφέας), Kristin E Poti (Συγγραφέας), Shannan L Rossi (Συγγραφέας), Nicholas Bergren (Συγγραφέας), Nikos Vasilakis (Συγγραφέας), George Dimopoulos (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Public Library of Science (PLoS), 2017-01-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

We have developed genetically modified Ae. aegypti mosquitoes that activate the conserved antiviral JAK/STAT pathway in the fat body tissue, by overexpressing either the receptor Dome or the Janus kinase Hop by the blood feeding-induced vitellogenin (Vg) promoter. Transgene expression inhibits infec...