Engineered Aedes aegypti JAK/STAT Pathway-Mediated Immunity to Dengue Virus.

• Main Authors: Natapong Jupatanakul (Author), Shuzhen Sim (Author), Yesseinia I Angleró-Rodríguez (Author), Jayme Souza-Neto (Author), Suchismita Das (Author), Kristin E Poti (Author), Shannan L Rossi (Author), Nicholas Bergren (Author), Nikos Vasilakis (Author), George Dimopoulos (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We have developed genetically modified Ae. aegypti mosquitoes that activate the conserved antiviral JAK/STAT pathway in the fat body tissue, by overexpressing either the receptor Dome or the Janus kinase Hop by the blood feeding-induced vitellogenin (Vg) promoter. Transgene expression inhibits infec...