Tall Cell Carcinoma with Reverse Polarity of Breast: Report of a Case with Unique Morphologic and Molecular Features

• Main Authors: Mohamed JASSIM (Author), Chennagiri S PREMALATA (Author), Geeta V Patil OKALY (Author), Chunduri SRINIVAS (Author)
• Format: Book
• Published: Federation of Turkish Pathology Societies, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 1018-5615; 1309-5730; 10.5146/tjpath.2020.01511
• Keywords: breast carcinoma; tall cell carcinoma; reverse polarity; solid papillary; idh2; Pathology; RB1-214
• Source: Türk Patoloji Dergisi, Vol 37, Iss 2, Pp 183-188 (2021)

Breast carcinomas are a heterogeneous group of malignancy, having variable clinical outcomes depending on their cellular and molecular properties. Tall cell carcinoma with reverse polarity (TCCRP) is a recently described rare entity, which shares morphological features with tall cell variant of papillary thyroid carcinoma but has a distinct morphological, immunohistochemical, and molecular profile. We describe a case of a 40-year-old female patient, who presented with lump in the breast. The patient underwent lumpectomy and was diagnosed as tall cell carcinoma with reverse polarity. Immunohistochemistry and bi-directional Sanger sequencing for IDH2 mutation were used for diagnosis. Tall cell carcinoma with reverse polarity is a rare and newly described entity with characteristic morphological and molecular findings, which carries an excellent prognosis.