Chronic otitis media is initiated by a bulla cavitation defect in the FBXO11 mouse model

• Váldodahkkit: Jorge del-Pozo (Dahkki), Neil MacIntyre (Dahkki), Ali Azar (Dahkki), James Glover (Dahkki), Elspeth Milne (Dahkki), Michael Cheeseman (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: The Company of Biologists, 2019-03-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Auditory bulla cavitation defects are a cause of otitis media, but the normal cellular pattern of bulla mesenchyme regression and its failure are not well understood. In mice, neural-crest-derived mesenchyme occupies the bulla from embryonic day 17.5 (E17.5) to postnatal day 11 (P11) and then regres...