Quantification of the Therapeutic Antibody Ocrelizumab in Mouse Brain Interstitial Fluid Using Cerebral Open Flow Microperfusion and Simultaneous Monitoring of the Blood-Brain Barrier Integrity

• Váldodahkkit: Thomas Altendorfer-Kroath (Dahkki), Joanna Hummer (Dahkki), Denise Kollmann (Dahkki), Beate Boulgaropoulos (Dahkki), Reingard Raml (Dahkki), Thomas Birngruber (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2023-07-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

The increasing relevance of improved therapeutic monoclonal antibodies (mAbs) to treat neurodegenerative diseases has strengthened the need to reliably measure their brain pharmacokinetic (PK) profiles. The aim of this study was, therefore, to absolutely quantify the therapeutic antibody ocrelizumab...