Biotransformation, Pharmacokinetics, and Pharmacological Activities of Ginsenoside Rd Against Multiple Diseases
Panax ginseng C.A. Mey. has a history of more than 4000 years and is widely used in Asian countries. Modern pharmacological studies have proved that ginsenosides and their compounds have a variety of significant biological activities on specific diseases, including neurodegenerative diseases, certai...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Book |
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Frontiers Media S.A.,
2022-07-01T00:00:00Z.
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| 042 | |a dc | ||
| 100 | 1 | 0 | |a Jing Li |e author |
| 700 | 1 | 0 | |a Qingxia Huang |e author |
| 700 | 1 | 0 | |a Qingxia Huang |e author |
| 700 | 1 | 0 | |a Yao Yao |e author |
| 700 | 1 | 0 | |a Peng Ji |e author |
| 700 | 1 | 0 | |a E. Mingyao |e author |
| 700 | 1 | 0 | |a Jinjin Chen |e author |
| 700 | 1 | 0 | |a Zepeng Zhang |e author |
| 700 | 1 | 0 | |a Zepeng Zhang |e author |
| 700 | 1 | 0 | |a Hongyu Qi |e author |
| 700 | 1 | 0 | |a Jiaqi Liu |e author |
| 700 | 1 | 0 | |a Zhaoqiang Chen |e author |
| 700 | 1 | 0 | |a Daqing Zhao |e author |
| 700 | 1 | 0 | |a Lei Zhou |e author |
| 700 | 1 | 0 | |a Xiangyan Li |e author |
| 245 | 0 | 0 | |a Biotransformation, Pharmacokinetics, and Pharmacological Activities of Ginsenoside Rd Against Multiple Diseases |
| 260 | |b Frontiers Media S.A., |c 2022-07-01T00:00:00Z. | ||
| 500 | |a 1663-9812 | ||
| 500 | |a 10.3389/fphar.2022.909363 | ||
| 520 | |a Panax ginseng C.A. Mey. has a history of more than 4000 years and is widely used in Asian countries. Modern pharmacological studies have proved that ginsenosides and their compounds have a variety of significant biological activities on specific diseases, including neurodegenerative diseases, certain types of cancer, gastrointestinal disease, and metabolic diseases, in which most of the interest has focused on ginsenoside Rd. The evidentiary basis showed that ginsenoside Rd ameliorates ischemic stroke, nerve injury, cancer, and other diseases involved in apoptosis, inflammation, oxidative stress, mitochondrial damage, and autophagy. In this review, we summarized available reports on the molecular biological mechanisms of ginsenoside Rd in neurological diseases, cancer, metabolic diseases, and other diseases. We also discussed the main biotransformation pathways of ginsenoside Rd obtained by fermentation. | ||
| 546 | |a EN | ||
| 690 | |a Panax ginseng C.A. Mey. | ||
| 690 | |a ginsenoside Rd | ||
| 690 | |a biotransformation | ||
| 690 | |a pharmacokinetics | ||
| 690 | |a molecular mechanisms | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Frontiers in Pharmacology, Vol 13 (2022) | |
| 787 | 0 | |n https://www.frontiersin.org/articles/10.3389/fphar.2022.909363/full | |
| 787 | 0 | |n https://doaj.org/toc/1663-9812 | |
| 856 | 4 | 1 | |u https://doaj.org/article/3bc39127e9e54d34b42c0ca8420df1a5 |z Connect to this object online. |