A nano-cocrystal strategy to improve the dissolution rate and oral bioavailability of baicalein

• Main Authors: Jiaxin Pi (Author), Shuya Wang (Author), Wen Li (Author), Dereje Kebebe (Author), Ying Zhang (Author), Bing Zhang (Author), Dongli Qi (Author), Pan Guo (Author), Nan Li (Author), Zhidong Liu (Author)
• Format: Book
• Published: Elsevier, 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Baicalein (BE) is one of the main active flavonoids representing the variety of pharmacological effects including anticancer, anti-inflammatory and cardiovascular protective activities, but it's very low solubility, dissolution rate and poor oral absorption limit the therapeutic applications. I...