Cyclin-Dependent Kinase Inhibitors and Their Therapeutic Potential in Colorectal Cancer Treatment

• Main Authors: Oana-Maria Thoma (Author), Markus F. Neurath (Author), Maximilian J. Waldner (Author)
• Format: Bog
• Udgivet: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• Fag: article
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Cyclin-dependent kinases (CDKs) are key players in cell cycle regulation. So far, more than ten CDKs have been described. Their direct interaction with cyclins allow progression through G1 phase, transitions to S and G2 phase and finally through mitosis (M). While CDK activation is important in cell...