Bacterial Protein Tyrosine Phosphatases as Possible Targets for Antimicrobial Therapies in Response to Antibiotic Resistance

• Main Authors: Alicja Kuban-Jankowska (Author), Tomasz Kostrzewa (Author), Magdalena Gorska-Ponikowska (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 10.3390/antiox11122397; 2076-3921
• Keywords: protein tyrosine phosphatase; reversible oxidation; bacterial phosphatase; virulence factor; antimicrobial therapy; Therapeutics. Pharmacology; RM1-950
• Source: Antioxidants, Vol 11, Iss 12, p 2397 (2022)

The review is focused on the bacterial protein tyrosine phosphatases (PTPs) utilized by bacteria as virulence factors necessary for pathogenicity. The inhibition of bacterial PTPs could contribute to the arrest of the bacterial infection process. This mechanism could be utilized in the design of antimicrobial therapy as adjuvants to antibiotics. The review summaries knowledge on pathogenic bacterial protein tyrosine phosphatases (PTPs) involved in infection process, such as: PTPA and PTPB from <i>Staphylococcus aureus</i> and <i>Mycobacterium tuberculosis</i>; SptP from <i>Salmonella typhimurium</i>; YopH from <i>Yersinia</i> sp. and TbpA from <i>Pseudomonas aeruginosa</i>. The review focuses also on the potential inhibitory compounds of bacterial virulence factors and inhibitory mechanisms such as the reversible oxidation of tyrosine phosphatases.