Prediction of gastric pH‐mediated drug exposure using physiologically‐based pharmacokinetic modeling: A case study of itraconazole
Abstract Abnormal gastric acidity, including achlorhydria, can act as a significant source of variability in orally administered drugs especially with pH‐sensitive solubility profiles, such as weak bases, potentially resulting in an undesirable therapeutic response. This study aimed to evaluate the...
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| Main Authors: | , , |
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| Format: | Book |
| Published: |
Wiley,
2023-06-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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