Quantum chemical calculations of nitrosamine activation and deactivation pathways for carcinogenicity risk assessment

N-nitrosamines and nitrosamine drug substance related impurities (NDSRIs) became a critical topic for the development and safety of small molecule medicines following the withdrawal of various pharmaceutical products from the market. To assess the mutagenic and carcinogenic potential of different N-...

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Autores principales: Andreas H. Göller (Autor), Sandra Johanssen (Autor), Adam Zalewski (Autor), Verena Ziegler (Autor)
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Publicado: Frontiers Media S.A., 2024-07-01T00:00:00Z.
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