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Tizoxanide Promotes Apoptosis in Glioblastoma by Inhibiting CDK1 Activity

The antiparasitic drug nitazoxanide (NTZ) has received considerable attention for its potential in cancer therapy. In this study, we demonstrate that tizoxanide (TIZ), an active metabolite of NTZ, exhibits antiglioma activity in vitro and in vivo by inducing G2/M cell cycle arrest and apoptosis. In...

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Bibliographic Details
Main Authors: Si Huang (Author), Jingxian Xiao (Author), Junyong Wu (Author), Jiayi Liu (Author), Xueping Feng (Author), Chengdong Yang (Author), Daxiong Xiang (Author), Shilin Luo (Author)
Format: Book
Published: Frontiers Media S.A., 2022-05-01T00:00:00Z.
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