2D/3D-QSAR Model Development Based on a Quinoline Pharmacophoric Core for the Inhibition of <i>Plasmodium falciparum</i>: An In Silico Approach with Experimental Validation

• Main Authors: Marcos Lorca (Author), Gisela C. Muscia (Author), Susana Pérez-Benavente (Author), José M. Bautista (Author), Alison Acosta (Author), Cesar González (Author), Gianfranco Sabadini (Author), Jaime Mella (Author), Silvia E. Asís (Author), Marco Mellado (Author)
• Format: Book
• Published: MDPI AG, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Malaria is an infectious disease caused by <i>Plasmodium</i> spp. parasites, with widespread drug resistance to most antimalarial drugs. We report the development of two 3D-QSAR models based on comparative molecular field analysis (CoMFA), comparative molecular similarity index analysis...