Preparation and Characterisation of Zinc Diethyldithiocarbamate-Cyclodextrin Inclusion Complexes for Potential Lung Cancer Treatment

• Main Authors: Ayşe Kaya (Author), Basel Arafat (Author), Havovi Chichger (Author), Ibrahim Tolaymat (Author), Barbara Pierscionek (Author), Mouhamad Khoder (Author), Mohammad Najlah (Author)
• Format: Book
• Published: MDPI AG, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Zinc diethyldithiocarbamate (Zn (DDC)₂), a disulfiram metabolite (anti-alcoholism drug), has shown a strong anti-cancer activity in vitro. However, its application was limited by its low aqueous solubility and rapid metabolism. In this study, the solubility enhancement of Zn (...