Amoxicillin Inactivation by Thiol-Catalyzed Cyclization Reduces Protein Haptenation and Antibacterial Potency

• Main Authors: María A. Pajares (Author), Tahl Zimmerman (Author), Francisco J. Sánchez-Gómez (Author), Adriana Ariza (Author), María J. Torres (Author), Miguel Blanca (Author), F. Javier Cañada (Author), María I. Montañez (Author), Dolores Pérez-Sala (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Serum and cellular proteins are targets for the formation of adducts with the β-lactam antibiotic amoxicillin. This process could be important for the development of adverse, and in particular, allergic reactions to this antibiotic. In studies exploring protein haptenation by amoxicillin, we observe...