Amoxicillin Inactivation by Thiol-Catalyzed Cyclization Reduces Protein Haptenation and Antibacterial Potency

• Váldodahkkit: María A. Pajares (Dahkki), Tahl Zimmerman (Dahkki), Francisco J. Sánchez-Gómez (Dahkki), Adriana Ariza (Dahkki), María J. Torres (Dahkki), Miguel Blanca (Dahkki), F. Javier Cañada (Dahkki), María I. Montañez (Dahkki), Dolores Pérez-Sala (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Frontiers Media S.A., 2020-03-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Serum and cellular proteins are targets for the formation of adducts with the β-lactam antibiotic amoxicillin. This process could be important for the development of adverse, and in particular, allergic reactions to this antibiotic. In studies exploring protein haptenation by amoxicillin, we observe...