Association of citrulline concentration at birth with lower respiratory tract infection in infancy: Findings from a multi-site birth cohort study

• Main Authors: Brittney M. Snyder (Author), Tebeb Gebretsadik (Author), Kedir N. Turi (Author), Christopher McKennan (Author), Suzanne Havstad (Author), Daniel J. Jackson (Author), Carole Ober (Author), Susan Lynch (Author), Kathryn McCauley (Author), Christine M. Seroogy (Author), Edward M. Zoratti (Author), Gurjit K. Khurana Hershey (Author), Sergejs Berdnikovs (Author), Gary Cunningham (Author), Marshall L. Summar (Author), James E. Gern (Author), Tina V. Hartert (Author), on behalf of the ECHO-CREW investigators (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Assessing the association of the newborn metabolic state with severity of subsequent respiratory tract infection may provide important insights on infection pathogenesis. In this multi-site birth cohort study, we identified newborn metabolites associated with lower respiratory tract infection (LRTI) in the first year of life in a discovery cohort and assessed for replication in two independent cohorts. Increased citrulline concentration was associated with decreased odds of LRTI (discovery cohort: aOR 0.83 [95% CI 0.70-0.99], p = 0.04; replication cohorts: aOR 0.58 [95% CI 0.28-1.22], p = 0.15). While our findings require further replication and investigation of mechanisms of action, they identify a novel target for LRTI prevention and treatment.

Item Description

2296-2360
10.3389/fped.2022.979777