iNOS/NO is required for IRF1 activation in response to liver ischemia-reperfusion in mice

• Main Authors: Qiang Du (Author), Jing Luo (Author), Mu-Qing Yang (Author), Quan Liu (Author), Caroline Heres (Author), Yi-He Yan (Author), Donna Stolz (Author), David A. Geller (Author)
• Format: Book
• Published: BMC, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Ischemia and reperfusion (I/R) induces cytokines, and up-regulates inducible nitric oxide synthase (iNOS), interferon regulatory factor-1(IRF1) and p53 up-regulated modulator of apoptosis (PUMA), which contribute to cell death and tissue injury. However, the mechanisms that I/R i...