Metformin attenuates fibroblast activation during pulmonary fibrosis by targeting S100A4 via AMPK-STAT3 axis

• المؤلفون الرئيسيون: Huimin Ji (مؤلف), Hongliang Dong (مؤلف), Yuejiao Lan (مؤلف), Yuqian Bi (مؤلف), Xuan Gu (مؤلف), Yongyue Han (مؤلف), Chongyang Yang (مؤلف), Minghan Cheng (مؤلف), Jian Gao (مؤلف)
• التنسيق: كتاب
• منشور في: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Fibroblasts activation is a crucial process for development of fibrosis during idiopathic pulmonary fibrosis pathogenesis, and transforming growth factor (TGF)-β1 plays a key regulatory role in fibroblast activation. It has been reported that metformin (MET) alleviated bleomycin (BLM)-induced pulmon...