Metformin attenuates fibroblast activation during pulmonary fibrosis by targeting S100A4 via AMPK-STAT3 axis

• প্রধান লেখক: Huimin Ji (লেখক), Hongliang Dong (লেখক), Yuejiao Lan (লেখক), Yuqian Bi (লেখক), Xuan Gu (লেখক), Yongyue Han (লেখক), Chongyang Yang (লেখক), Minghan Cheng (লেখক), Jian Gao (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Fibroblasts activation is a crucial process for development of fibrosis during idiopathic pulmonary fibrosis pathogenesis, and transforming growth factor (TGF)-β1 plays a key regulatory role in fibroblast activation. It has been reported that metformin (MET) alleviated bleomycin (BLM)-induced pulmon...