Metformin attenuates fibroblast activation during pulmonary fibrosis by targeting S100A4 via AMPK-STAT3 axis

• Hlavní autoři: Huimin Ji (Autor), Hongliang Dong (Autor), Yuejiao Lan (Autor), Yuqian Bi (Autor), Xuan Gu (Autor), Yongyue Han (Autor), Chongyang Yang (Autor), Minghan Cheng (Autor), Jian Gao (Autor)
• Médium: Kniha
• Vydáno: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Fibroblasts activation is a crucial process for development of fibrosis during idiopathic pulmonary fibrosis pathogenesis, and transforming growth factor (TGF)-β1 plays a key regulatory role in fibroblast activation. It has been reported that metformin (MET) alleviated bleomycin (BLM)-induced pulmon...