Metformin attenuates fibroblast activation during pulmonary fibrosis by targeting S100A4 via AMPK-STAT3 axis

• Prif Awduron: Huimin Ji (Awdur), Hongliang Dong (Awdur), Yuejiao Lan (Awdur), Yuqian Bi (Awdur), Xuan Gu (Awdur), Yongyue Han (Awdur), Chongyang Yang (Awdur), Minghan Cheng (Awdur), Jian Gao (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Fibroblasts activation is a crucial process for development of fibrosis during idiopathic pulmonary fibrosis pathogenesis, and transforming growth factor (TGF)-β1 plays a key regulatory role in fibroblast activation. It has been reported that metformin (MET) alleviated bleomycin (BLM)-induced pulmon...