Metformin attenuates fibroblast activation during pulmonary fibrosis by targeting S100A4 via AMPK-STAT3 axis

• Hauptverfasser: Huimin Ji (Verfasst von), Hongliang Dong (Verfasst von), Yuejiao Lan (Verfasst von), Yuqian Bi (Verfasst von), Xuan Gu (Verfasst von), Yongyue Han (Verfasst von), Chongyang Yang (Verfasst von), Minghan Cheng (Verfasst von), Jian Gao (Verfasst von)
• Format: Buch
• Veröffentlicht: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Fibroblasts activation is a crucial process for development of fibrosis during idiopathic pulmonary fibrosis pathogenesis, and transforming growth factor (TGF)-β1 plays a key regulatory role in fibroblast activation. It has been reported that metformin (MET) alleviated bleomycin (BLM)-induced pulmon...