Metformin attenuates fibroblast activation during pulmonary fibrosis by targeting S100A4 via AMPK-STAT3 axis

• Κύριοι συγγραφείς: Huimin Ji (Συγγραφέας), Hongliang Dong (Συγγραφέας), Yuejiao Lan (Συγγραφέας), Yuqian Bi (Συγγραφέας), Xuan Gu (Συγγραφέας), Yongyue Han (Συγγραφέας), Chongyang Yang (Συγγραφέας), Minghan Cheng (Συγγραφέας), Jian Gao (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Fibroblasts activation is a crucial process for development of fibrosis during idiopathic pulmonary fibrosis pathogenesis, and transforming growth factor (TGF)-β1 plays a key regulatory role in fibroblast activation. It has been reported that metformin (MET) alleviated bleomycin (BLM)-induced pulmon...