Metformin attenuates fibroblast activation during pulmonary fibrosis by targeting S100A4 via AMPK-STAT3 axis

• Main Authors: Huimin Ji (Author), Hongliang Dong (Author), Yuejiao Lan (Author), Yuqian Bi (Author), Xuan Gu (Author), Yongyue Han (Author), Chongyang Yang (Author), Minghan Cheng (Author), Jian Gao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fibroblasts activation is a crucial process for development of fibrosis during idiopathic pulmonary fibrosis pathogenesis, and transforming growth factor (TGF)-β1 plays a key regulatory role in fibroblast activation. It has been reported that metformin (MET) alleviated bleomycin (BLM)-induced pulmon...