Metformin attenuates fibroblast activation during pulmonary fibrosis by targeting S100A4 via AMPK-STAT3 axis

• Päätekijät: Huimin Ji (Tekijä), Hongliang Dong (Tekijä), Yuejiao Lan (Tekijä), Yuqian Bi (Tekijä), Xuan Gu (Tekijä), Yongyue Han (Tekijä), Chongyang Yang (Tekijä), Minghan Cheng (Tekijä), Jian Gao (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Fibroblasts activation is a crucial process for development of fibrosis during idiopathic pulmonary fibrosis pathogenesis, and transforming growth factor (TGF)-β1 plays a key regulatory role in fibroblast activation. It has been reported that metformin (MET) alleviated bleomycin (BLM)-induced pulmon...