Metformin attenuates fibroblast activation during pulmonary fibrosis by targeting S100A4 via AMPK-STAT3 axis

• Auteurs principaux: Huimin Ji (Auteur), Hongliang Dong (Auteur), Yuejiao Lan (Auteur), Yuqian Bi (Auteur), Xuan Gu (Auteur), Yongyue Han (Auteur), Chongyang Yang (Auteur), Minghan Cheng (Auteur), Jian Gao (Auteur)
• Format: Livre
• Publié: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Fibroblasts activation is a crucial process for development of fibrosis during idiopathic pulmonary fibrosis pathogenesis, and transforming growth factor (TGF)-β1 plays a key regulatory role in fibroblast activation. It has been reported that metformin (MET) alleviated bleomycin (BLM)-induced pulmon...