Metformin attenuates fibroblast activation during pulmonary fibrosis by targeting S100A4 via AMPK-STAT3 axis

• Príomhchruthaitheoirí: Huimin Ji (Údar), Hongliang Dong (Údar), Yuejiao Lan (Údar), Yuqian Bi (Údar), Xuan Gu (Údar), Yongyue Han (Údar), Chongyang Yang (Údar), Minghan Cheng (Údar), Jian Gao (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

Fibroblasts activation is a crucial process for development of fibrosis during idiopathic pulmonary fibrosis pathogenesis, and transforming growth factor (TGF)-β1 plays a key regulatory role in fibroblast activation. It has been reported that metformin (MET) alleviated bleomycin (BLM)-induced pulmon...