Metformin attenuates fibroblast activation during pulmonary fibrosis by targeting S100A4 via AMPK-STAT3 axis

• Autori principali: Huimin Ji (Autore), Hongliang Dong (Autore), Yuejiao Lan (Autore), Yuqian Bi (Autore), Xuan Gu (Autore), Yongyue Han (Autore), Chongyang Yang (Autore), Minghan Cheng (Autore), Jian Gao (Autore)
• Natura: Libro
• Pubblicazione: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Fibroblasts activation is a crucial process for development of fibrosis during idiopathic pulmonary fibrosis pathogenesis, and transforming growth factor (TGF)-β1 plays a key regulatory role in fibroblast activation. It has been reported that metformin (MET) alleviated bleomycin (BLM)-induced pulmon...