Metformin attenuates fibroblast activation during pulmonary fibrosis by targeting S100A4 via AMPK-STAT3 axis

• 主要な著者: Huimin Ji (著者), Hongliang Dong (著者), Yuejiao Lan (著者), Yuqian Bi (著者), Xuan Gu (著者), Yongyue Han (著者), Chongyang Yang (著者), Minghan Cheng (著者), Jian Gao (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Fibroblasts activation is a crucial process for development of fibrosis during idiopathic pulmonary fibrosis pathogenesis, and transforming growth factor (TGF)-β1 plays a key regulatory role in fibroblast activation. It has been reported that metformin (MET) alleviated bleomycin (BLM)-induced pulmon...