Metformin attenuates fibroblast activation during pulmonary fibrosis by targeting S100A4 via AMPK-STAT3 axis

• Үндсэн зохиолчид: Huimin Ji (Зохиогч), Hongliang Dong (Зохиогч), Yuejiao Lan (Зохиогч), Yuqian Bi (Зохиогч), Xuan Gu (Зохиогч), Yongyue Han (Зохиогч), Chongyang Yang (Зохиогч), Minghan Cheng (Зохиогч), Jian Gao (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Fibroblasts activation is a crucial process for development of fibrosis during idiopathic pulmonary fibrosis pathogenesis, and transforming growth factor (TGF)-β1 plays a key regulatory role in fibroblast activation. It has been reported that metformin (MET) alleviated bleomycin (BLM)-induced pulmon...