Metformin attenuates fibroblast activation during pulmonary fibrosis by targeting S100A4 via AMPK-STAT3 axis

• Главные авторы: Huimin Ji (Автор), Hongliang Dong (Автор), Yuejiao Lan (Автор), Yuqian Bi (Автор), Xuan Gu (Автор), Yongyue Han (Автор), Chongyang Yang (Автор), Minghan Cheng (Автор), Jian Gao (Автор)
• Формат: ‌
• Опубликовано: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Fibroblasts activation is a crucial process for development of fibrosis during idiopathic pulmonary fibrosis pathogenesis, and transforming growth factor (TGF)-β1 plays a key regulatory role in fibroblast activation. It has been reported that metformin (MET) alleviated bleomycin (BLM)-induced pulmon...