Metformin attenuates fibroblast activation during pulmonary fibrosis by targeting S100A4 via AMPK-STAT3 axis

• Váldodahkkit: Huimin Ji (Dahkki), Hongliang Dong (Dahkki), Yuejiao Lan (Dahkki), Yuqian Bi (Dahkki), Xuan Gu (Dahkki), Yongyue Han (Dahkki), Chongyang Yang (Dahkki), Minghan Cheng (Dahkki), Jian Gao (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Fibroblasts activation is a crucial process for development of fibrosis during idiopathic pulmonary fibrosis pathogenesis, and transforming growth factor (TGF)-β1 plays a key regulatory role in fibroblast activation. It has been reported that metformin (MET) alleviated bleomycin (BLM)-induced pulmon...