Metformin attenuates fibroblast activation during pulmonary fibrosis by targeting S100A4 via AMPK-STAT3 axis

• Asıl Yazarlar: Huimin Ji (Yazar), Hongliang Dong (Yazar), Yuejiao Lan (Yazar), Yuqian Bi (Yazar), Xuan Gu (Yazar), Yongyue Han (Yazar), Chongyang Yang (Yazar), Minghan Cheng (Yazar), Jian Gao (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Fibroblasts activation is a crucial process for development of fibrosis during idiopathic pulmonary fibrosis pathogenesis, and transforming growth factor (TGF)-β1 plays a key regulatory role in fibroblast activation. It has been reported that metformin (MET) alleviated bleomycin (BLM)-induced pulmon...