Genetic profile of sports climbing athletes from three different ethnicities
This study aimed to investigate the ACTN3 R577X, ACE I/D, CKM rs8111989, and TRHR rs7832552 genotypes in climbers and controls in three ethnicities. The study consisted of 258 climbers (Japanese, n = 100; Polish, n = 128; Russian, n = 30) and 1151 controls (Japanese: n = 332, Polish: n = 635, Russia...
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| Main Authors: | , , , , , , , , , , , , , , |
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Termedia Publishing House,
2021-11-01T00:00:00Z.
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| 001 | doaj_3d1cdd32a81e4f7ab66f6a6f0ed3cf4a | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Mika Saito |e author |
| 700 | 1 | 0 | |a Michał Ginszt |e author |
| 700 | 1 | 0 | |a Ekaterina Semenova |e author |
| 700 | 1 | 0 | |a Myosotis Massidda |e author |
| 700 | 1 | 0 | |a Kinga Huminska-Lisowska |e author |
| 700 | 1 | 0 | |a Monika Michałowska-Sawczyn |e author |
| 700 | 1 | 0 | |a Hiroki Homma |e author |
| 700 | 1 | 0 | |a Paweł Cięszczyk |e author |
| 700 | 1 | 0 | |a Takanobu Okamoto |e author |
| 700 | 1 | 0 | |a Andrey Larin |e author |
| 700 | 1 | 0 | |a Edward Generozov |e author |
| 700 | 1 | 0 | |a Piotr Majcher |e author |
| 700 | 1 | 0 | |a Koichi Nakazato |e author |
| 700 | 1 | 0 | |a Ildus Ahmetov |e author |
| 700 | 1 | 0 | |a Naoki Kikuchi |e author |
| 245 | 0 | 0 | |a Genetic profile of sports climbing athletes from three different ethnicities |
| 260 | |b Termedia Publishing House, |c 2021-11-01T00:00:00Z. | ||
| 500 | |a 0860-021X | ||
| 500 | |a 2083-1862 | ||
| 500 | |a 10.5114/biolsport.2022.109958 | ||
| 520 | |a This study aimed to investigate the ACTN3 R577X, ACE I/D, CKM rs8111989, and TRHR rs7832552 genotypes in climbers and controls in three ethnicities. The study consisted of 258 climbers (Japanese, n = 100; Polish, n = 128; Russian, n = 30) and 1151 controls (Japanese: n = 332, Polish: n = 635, Russian: n = 184). Genotyping results were analyzed using the TaqMan approach in Japanese and Polish subjects and HumanOmni1-Quad Bead Chips in Russian subjects. There were no significant differences in ACTN3 R577X and ACE I/D polymorphism distribution between climbers and controls in any ethnic cohort or model. The frequencies of the C allele in the CKM polymorphism and the T allele in the TRHR polymorphism were higher in climbers than in controls only in the Russian cohort (p = 0.045 and p = 0.039, respectively). The results of the meta analysis on three cohorts showed that the frequency of XX+RX genotypes in the ACTN3 R577X polymorphism was significantly higher in climbers than that in the controls (p = 0.01). The X allele of the ACTN3 R577X polymorphism was associated with sport climbing status, as assessed using a meta-analysis of climbers across three different ethnicities. | ||
| 546 | |a EN | ||
| 690 | |a sports climbing | ||
| 690 | |a polymorphism | ||
| 690 | |a actn3 | ||
| 690 | |a ace | ||
| 690 | |a ckm | ||
| 690 | |a trhr | ||
| 690 | |a Sports medicine | ||
| 690 | |a RC1200-1245 | ||
| 690 | |a Biology (General) | ||
| 690 | |a QH301-705.5 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Biology of Sport, Vol 39, Iss 4, Pp 913-919 (2021) | |
| 787 | 0 | |n https://www.termedia.pl/Genetic-profile-of-sports-climbing-athletes-from-three-different-ethnicities,78,45419,1,1.html | |
| 787 | 0 | |n https://doaj.org/toc/0860-021X | |
| 787 | 0 | |n https://doaj.org/toc/2083-1862 | |
| 856 | 4 | 1 | |u https://doaj.org/article/3d1cdd32a81e4f7ab66f6a6f0ed3cf4a |z Connect to this object online. |