Hepatobiliary Involvement in Neonates With COVID-19 Infection: A Previous Case Series Studies

• Main Author: Roya Farhadi (Author)
• Format: Book
• Published: Mazandaran University of Medical Sciences, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2322-4398; 2322-4401
• Keywords: covid-19; hepatitis; liver diseases; newborn; sars-cov-2; transaminases; Pediatrics; RJ1-570
• Source: Journal of Pediatrics Review, Vol 11, Iss 2, Pp 125-134 (2023)

Background: The most common symptoms in neonates with severe COVID-19 infection have been respiratory problems. The virus may adversely affect organs such as the liver. Methods: Studies focusing solely on liver involvement in newborns with COVID-19 infection were searched in Pubmed, Scopus, and Google Scholar databases. Eight studies were finally reviewed. Results: Direct viral invasion (COVID-19-induced hepatitis or systemic inflammatory response) and drug-induced may contribute to liver damage in neonates. SARS-CoV-2 may be the latest spark in toxoplasmosis, other agents, rubella, cytomegalovirus, herpes infections, and fetal liver involvement may be induced by transplacental transmission. Conclusions: Hepatic dysfunction is infrequent but important in neonates with COVID-19 infection and the mechanism of liver damage associated with COVID-19 may differ from that in adults.