A missense mutation of the gene encoding synaptic vesicle glycoprotein 2A (SV2A) confers seizure susceptibility by disrupting amygdalar synaptic GABA release

• Главные авторы: Kentaro Tokudome (Автор), Takahiro Okumura (Автор), Ryo Terada (Автор), Saki Shimizu (Автор), Naofumi Kunisawa (Автор), Tomoji Mashimo (Автор), Tadao Serikawa (Автор), Masashi Sasa (Автор), Yukihiro Ohno (Автор)
• Формат: ‌
• Опубликовано: Frontiers Media S.A., 2016-07-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Synaptic vesicle glycoprotein 2A (SV2A) is specifically expressed in the membranes of synaptic vesicles and modulates action potential-dependent neurotransmitter release. To explore the role of SV2A in the pathogenesis of epileptic disorders, we recently generated a novel rat model (Sv2aL174Q rat) c...