Multifunctional oral delivery systems for enhanced bioavailability of therapeutic peptides/proteins
In last few years, therapeutic peptides/proteins are rapidly growing in drug market considering their higher efficiency and lower toxicity than chemical drugs. However, the administration of therapeutic peptides/proteins is mainly limited in parenteral approach. Oral therapy which was hampered by ha...
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| Main Authors: | , , , , , , , |
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| Format: | Book |
| Published: |
Elsevier,
2019-09-01T00:00:00Z.
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| Subjects: | |
| Online Access: | Connect to this object online. |
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| Summary: | In last few years, therapeutic peptides/proteins are rapidly growing in drug market considering their higher efficiency and lower toxicity than chemical drugs. However, the administration of therapeutic peptides/proteins is mainly limited in parenteral approach. Oral therapy which was hampered by harsh gastrointestinal environment and poorly penetrating epithelial barriers often results in low bioavailability (less than 1%-2%). Therefore, delivery systems that are rationally designed to overcome these challenges in gastrointestinal tract and ameliorate the oral bioavailability of therapeutic peptides/proteins are seriously promising. In this review, we summarized various multifunctional delivery systems, including lipid-based particles, polysaccharide-based particles, inorganic particles, and synthetic multifunctional particles that achieved effective oral delivery of therapeutic peptides/proteins. KEY WORDS: Multifunctional delivery systems, Oral, Bioavailability, Macromolecules, Peptides and proteins, Gastrointestinal environment, Epithelial barriers, Nanoparticles |
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| Item Description: | 2211-3835 10.1016/j.apsb.2019.01.004 |