Intracerebroventricular injection of RFRP-3 delays puberty onset and stimulates growth hormone secretion in female rats

• Main Authors: Xinghui Han (Author), Yuanyuan He (Author), Gulan Zeng (Author), Yonghong Wang (Author), Wen Sun (Author), Junchao Liu (Author), Yanyan Sun (Author), Jian Yu (Author)
• Format: Bog
• Udgivet: BMC, 2017-05-01T00:00:00Z.
• Fag: article
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Abstract Background Puberty onset is a complex, organized biological process with multilevel regulation, and its physiopathological mechanisms are yet to be elucidated. RFRP-3, the mammalian ortholog to gonadotropin-inhibitory hormone, is implicated in inhibiting the synthesis and release of gonadot...