Intracerebroventricular injection of RFRP-3 delays puberty onset and stimulates growth hormone secretion in female rats

• Egile Nagusiak: Xinghui Han (Egilea), Yuanyuan He (Egilea), Gulan Zeng (Egilea), Yonghong Wang (Egilea), Wen Sun (Egilea), Junchao Liu (Egilea), Yanyan Sun (Egilea), Jian Yu (Egilea)
• Formatua: Liburua
• Argitaratua: BMC, 2017-05-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Abstract Background Puberty onset is a complex, organized biological process with multilevel regulation, and its physiopathological mechanisms are yet to be elucidated. RFRP-3, the mammalian ortholog to gonadotropin-inhibitory hormone, is implicated in inhibiting the synthesis and release of gonadot...